Novel monomolecular derivatives of the anti-HIV-1 G-quadruplex-forming Hotoda’s aptamer containing inversion of polarity sites

Here we report on the design, preparation and investigation of four analogues of the anti-HIV G-quadruplex-forming Hotoda’s aptamer, based on an unprecedented linear topology. In these derivatives, four TGGGAGT tracts have been joined together by exploiting 3′-3′ and 5′-5′ inversion of polarity sites formed by canonical phosphodiester bonds or a glycerol-based linker. Circular dichroism data suggest that all oligodeoxynucleotides fold in...