Original paper
Synthesis and Biological Evaluation of a Carbamate-Containing Tubulysin Antibody–Drug Conjugate
Abstract
Antibody–drug conjugates (ADCs) use antibodies to deliver cytotoxic payloads directly into tumor cells via specifically binding to the target cell surface antigens. ADCs can enhance the anti-tumor effects of antibodies, and increase the delivery of cytotoxic payloads to cancer cells with a better therapeutic index. An ADC was prepared with a potent carbamate-containing tubulysin analogue attached to an anti-mesothelin antibody via a Cit-Val...
Paper Details
Title
Synthesis and Biological Evaluation of a Carbamate-Containing Tubulysin Antibody–Drug Conjugate
Published Date
Sep 3, 2020
Journal
Volume
31
Issue
10
Pages
2350 - 2361
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Notes
History