Endogenous Labile Iron Pool-Mediated Free Radical Generation for Cancer Chemodynamic Therapy

Volume: 142, Issue: 36, Pages: 15320 - 15330
Published: Aug 21, 2020
Abstract
Current chemodynamic therapy (CDT) primarily relies on the delivery of transition metal ions with Fenton activity to trigger hydroxyl radical production from hydrogen peroxide. However, administration of an excess amount of exogenous Fenton-type heavy metals may cause potential adverse effects to human health, including acute and chronic damages. Here, we present a new CDT strategy that uses intracellular labile iron pool (LIP) as the endogenous...
Paper Details
Title
Endogenous Labile Iron Pool-Mediated Free Radical Generation for Cancer Chemodynamic Therapy
Published Date
Aug 21, 2020
Volume
142
Issue
36
Pages
15320 - 15330
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