Pharmacodynamics and pharmacokinetics behaviour of insulin from PEGylated-mucin microparticles coated with pH sensitive polymer: Preparation and characterization

The aim of this study was to develop a mucin-PEG based microparticles for oral delivery system for insulin for diabetes treatment. Mucin-PEG microparticles were prepared using emulsion technique. These microparticles were coated with Hydroxyl propyl methylcellulose acetate succinate (HPMCAS) using solvent evaporation method. The effect of polymer ratios and coating were investigated in terms of size, surface morphology, entrapment efficiency,...