Novel rhein–phospholipid complex targeting skin diseases: development, in vitro, ex vivo, and in vivo studies

Rhein (RH), an anthraquinone derivative, has proven to be a promising molecule for treating several skin disorders thanks to its pleiotropic pharmacological activities like antimicrobial, antifungal, antioxidant, and anticancer. However, RH’s low water and oil solubility and poor skin permeability halted its topical delivery. This is the first work to investigate the expediency of tailoring a rhein–phospholipid complex (RH–PLC) to improve RH...