Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers
Abstract
There is an unmet clinical need for improved tissue and liquid biopsy tools for cancer detection. We investigated the proteomic profile of extracellular vesicles and particles (EVPs) in 426 human samples from tissue explants (TEs), plasma, and other bodily fluids. Among traditional exosome markers, CD9, HSPA8, ALIX, and HSP90AB1 represent pan-EVP markers, while ACTB, MSN, and RAP1B are novel pan-EVP markers. To confirm that EVPs are ideal...
Paper Details
Title
Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers
Published Date
Aug 1, 2020
Journal
Volume
182
Issue
4
Pages
1044 - 1061.e18
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