Coronavirus

Intensive care medicine

2019-20 coronavirus outbreak

Viral replication

Betacoronavirus

Virology

Clinical trial

Chronic hepatitis

Viral load

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

Outbreak

Drug

Antiviral drug

Coronavirus disease 2019 (COVID-19)

Immunology

Antiviral treatment

Infectious disease (medical specialty)

Internal medicine

Pharmacology

Medicine

Antiviral therapy

Virus

Disease

Pathology

Clinical Epidemiology and Global Health

BackgroundThe aim of this study was to summarize the antiviral activities of remdesivir against SARS-CoV-2, the causative agent of COVID-19.MethodsAvailable publications were systematically explored on some databases and gray literature was examined. Publications were discussed narratively.ResultsRemdesivir inhibits SARS-CoV-2 replication, reduces viral load, and exerts protective effects in SARS-CoV-2 infected animals. Remdesivir also reduces the pathological process, alleviates mild symptoms, and improves pulmonary lesions in SARS-CoV-2-infecetd animals. Remdesivir has been used as a compassionate drug for treating COVID-19 patients.ConclusionAlthough remdesivir has shown potent antiviral activities, more efficacy assessments are urgently warranted in clinical trials.

Remdesivir and its antiviral activity against COVID-19: A systematic review