Discovery of Sulfated Small Molecule Inhibitors of Matrix Metalloproteinase-8
Abstract
Elevated matrix metalloproteinase-8 (MMP-8) activity contributes to the etiology of many diseases, including atherosclerosis, pulmonary fibrosis, and sepsis. Yet, very few small molecule inhibitors of MMP-8 have been identified. We reasoned that the synthetic non-sugar mimetics of glycosaminoglycans may inhibit MMP-8 because natural glycosaminoglycans are known to modulate the functions of various MMPs. The screening a library of 58 synthetic,...
Paper Details
Title
Discovery of Sulfated Small Molecule Inhibitors of Matrix Metalloproteinase-8
Published Date
Aug 9, 2020
Journal
Volume
10
Issue
8
Pages
1166 - 1166
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