Investigation of Filamentous Basidiomycetes in the Airway Is the Third Unmet Need in the Management of Unexplained Chronic Cough in Adults.

Published on Aug 5, 2020
· DOI :10.1159/000508611
Haruhiko Ogawa17
Estimated H-index: 17
,
Kazuya Tone5
Estimated H-index: 5
,
Koichi Makimura36
Estimated H-index: 36
Source
Abstract
References9
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#1Richard S. Irwin (UMMS: University of Massachusetts Medical School)H-Index: 66
#2Cynthia L. French (UMMS: University of Massachusetts Medical School)H-Index: 7
Last. J. Mark Madison (UMMS: University of Massachusetts Medical School)H-Index: 17
view all 3 authors...
2 CitationsSource
#1Kenichiro Okumura (Kanazawa University)H-Index: 6
#2Haruhiko OgawaH-Index: 17
Last. Toshifumi Gabata (Kanazawa University)H-Index: 52
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Objectives This study was conducted in order to identify imaging features on three-dimensional computed tomography (CT) of unexplained chronic cough (UCC) patients with positive sputum cultures for filamentous Basidiomycetes (f-BM).
2 CitationsSource
#1Kazuya Tone (Teikyo University)H-Index: 5
#2Haruhiko OgawaH-Index: 17
Last. Koichi MakimuraH-Index: 36
view all 5 authors...
BACKGROUND: Filamentous basidiomycetes (f-BMs) are involved in some unexplained chronic cough (UCC) cases that can be improved by the administration of antifungal agents. The disease concept was termed fungus-associated chronic cough (FACC). The current diagnostic criteria warrant environmental fungi isolation from respiratory specimens, which is hardly conceivable for such fungi. OBJECTIVES: This study aimed to detect the f-BMs Bjerkandera adusta, the most common pathogen in FACC, from respirat...
1 CitationsSource
#1Haruhiko OgawaH-Index: 17
#2Kazuya Tone (Jikei University School of Medicine)H-Index: 5
Last. Koichi Makimura (Teikyo University)H-Index: 36
view all 4 authors...
2 CitationsSource
#1Richard S. IrwinH-Index: 66
#2Cynthia L. FrenchH-Index: 7
Last. Miles WeinbergerH-Index: 56
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Background We performed systematic reviews using the population, intervention, comparison, outcome (PICO) format to answer the following key clinical question: Are the CHEST 2006 classifications of acute, subacute and chronic cough and associated management algorithms in adults that were based on durations of cough useful? Methods We used the CHEST Expert Cough Panel's protocol for the systematic reviews and the American College of Chest Physicians (CHEST) methodological guidelines and Grading o...
131 CitationsSource
#1Anuradha Chowdhary (DU: University of Delhi)H-Index: 62
#2Kshitij Agarwal (DU: University of Delhi)H-Index: 15
Last. Jacques F. MeisH-Index: 103
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Respiratory tract infections are globally responsible for one-third of infectious disease–associated mortality, accounting for 4.3 million annual deaths. Among these, fungal infections of the respiratory tract are largely unrecognized, and the true burden is elusive [1]. Despite treatment, most invasive fungal infections are associated with high mortality rates of >50% [2]. In general, fungal infections of the respiratory tract are considered synonymous with invasive pulmonary infections caused ...
25 CitationsSource
#1Haruhiko OgawaH-Index: 17
#2Masaki FujimuraH-Index: 53
Last. Koichi Makimura (Teikyo University)H-Index: 36
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With regard to fungal colonization and fungal sensitization, the goals of fungus-associated asthma management are as follows: 1) to survey fungi colonizing the airways of patients repeatedly; 2) to evaluate the tendency of the colonizing fungi to sensitize patients and the influence on clinical manifestations of asthma; 3) to follow disease development to allergic bronchopulmonary mycosis or sinobronchial allergic mycosis; and 4) to determine whether fungal eradication from the airway of patient...
7 CitationsSource
#1Haruhiko OgawaH-Index: 17
#2Masaki FujimuraH-Index: 53
Last. Koichi Makimura (Teikyo University)H-Index: 36
view all 4 authors...
4 CitationsSource
#1Haruhiko OgawaH-Index: 17
#2Masaki Fujimura (Kanazawa University)H-Index: 53
Last. Koichi Makimura (Teikyo University)H-Index: 36
view all 4 authors...
Objectives. This controlled study was performed to clarify the therapeutic benefit of itraconazole for the treatment of patients with chronic cough, wherein a sputum culture yielded basidiomycetous (BM) fungi. Methods. Of the 171 patients who visited our hospital for the diagnosis and treatment of chronic cough, BM was detected in the sputum of 39 patients. Informed consents were obtained from 21 patients who were subsequently enrolled in this trial. After the administration of the standard ther...
34 CitationsSource
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