Optimization of phytic acid-crosslinked chitosan microspheres for oral insulin delivery using response surface methodology
Abstract
Although oral administration is favorable mode of insulin delivery, it is the most challenging route, owing to poor oral bioavailability. In this study, a chitosan (CS)-based insulin delivery system was developed by ionic crosslinking with phytic acid (PA). CS-PA microspheres were optimized with different crosslinking conditions of CS and PA using response surface methodology to retain insulin during preparation and gastric digestion....
Paper Details
Title
Optimization of phytic acid-crosslinked chitosan microspheres for oral insulin delivery using response surface methodology
Published Date
Oct 1, 2020
Volume
588
Pages
119736 - 119736
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