Functionalised calcium carbonate as a coformer to stabilize amorphous drugs by mechanochemical activation

The aim of this study was to investigate the amorphization, physical stability and drug release of a model drug, carvedilol (CAR), when loaded onto functionalised calcium carbonate (FCC) using mechanochemical activation (vibrational ball milling). The solid-state characteristics and physical stability of CAR–FCC samples, prepared at different weight ratios and for different milling times, were determined using differential scanning calorimetry...