European Journal of Pharmaceutics and Biopharmaceutics
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4892
Papers 5157
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Abstract In vitro dissolution tests are widely used to monitor the quality and consistency of oral solid dosage forms, but to increase the physiological relevance of in vitro dissolution tests, newer systems combine dissolution and permeation measurements. Some of these use artificial membranes while others (e.g., in the in vitro dissolution absorption system 2; IDAS2), utilize cell monolayers to assess drug permeation. We determined the effect of the precipitation inhibitor Hypromellose Acetate...
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#1Eva Aubets (University of Barcelona)H-Index: 2
#2Rosa Griera (University of Barcelona)H-Index: 12
Last. Carlos J. Ciudad (University of Barcelona)H-Index: 33
view all 11 authors...
Abstract Nucleic acids therapeutics provide a selective and promising alternative to traditional treatments for multiple genetic diseases. A major obstacle is the development of safe and efficient delivery systems. Here, we report the synthesis of the new cationic gemini amphiphile 1,3-bis[(4-oleyl-1-pyridinio)methyl]benzene dibromide (DOPY). Its transfection efficiency was evaluated using PolyPurine Reverse Hoogsteen hairpins (PPRHs), a nucleic acid tool for gene silencing and gene repair devel...
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#1Urvi Gala (Georgetown University)
#2Dave A. Miller (Georgetown University)H-Index: 20
Last. Robert O. Williams (University of Texas at Austin)H-Index: 61
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Abstract Abiraterone is a poorly water-soluble drug used in the treatment of prostate cancer. In our previous study, we reported that KinetiSol® processed solid dispersions (KSDs) based on hydroxypropyl β-cyclodextrin (HPBCD) showed improved dissolution and pharmacokinetics of abiraterone. However, the nature of abiraterone-HPBCD interaction within the KSDs or the effect of drug loading on the physicochemical properties and in vivo performance of HPBCD-based KSDs remain largely unknown. We hypot...
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#1Satish Rojekar ('QUB': Queen's University Belfast)
#2Lalitkumar K. Vora ('QUB': Queen's University Belfast)H-Index: 11
Last. Ryan F. Donnelly ('QUB': Queen's University Belfast)H-Index: 66
view all 7 authors...
Abstract A key challenge of HIV treatment with multiple antiretroviral drugs is patient adherence. Thus, there is an urgent need for long-acting depot systems for delivering drugs over an extended duration. Although the parenteral route is preferred for depot systems, it is associated with obvious drawbacks, such as painful injections, potentially-contaminated sharps waste, and the necessity of trained healthcare personnel for administration. Amongst a small number of alternatives in development...
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#1Md. Golam Kibria (TUAT: Tokyo University of Agriculture and Technology)H-Index: 2
#2Yoko Akazawa-Ogawa (AIST: National Institute of Advanced Industrial Science and Technology)H-Index: 8
Last. Yutaka Kuroda (TUAT: Tokyo University of Agriculture and Technology)H-Index: 24
view all 4 authors...
Abstract We previously demonstrated that amorphous aggregates of misfolded VHH-7D12 antibodies (VHH-Mis), a potential anti-EGFR drug, can generate a robust serum IgG response. Here we investigate the immunogenic nature, especially the specificity of the immune response induced by VHH-Mis. To this end, we used two natively folded and 77% identical anti-EGFR VHHs (VHH-7D12 and VHH-9G8) that possess a common framework but distinct complementarity determining regions (CDRs). In 60% of mice immunized...
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#1Meenakshi Goel (Genentech)H-Index: 3
#2Dennis H. Leung (Genentech)H-Index: 13
Last. Mohammad A. Al-Sayah (Genentech)H-Index: 5
view all 6 authors...
Abstract Poly (lactic-co-glycolic acid) (PLGA), a biocompatible and biodegradable polymer, is one of the most commonly used vehicles for controlled-release (CR) implantable dosage forms. Drug molecules formulated in such CR vehicles are released slowly over an extended period of time - often months to years - posing challenges for batch release and quality control testing. Thus, reliable and reproducible accelerated testing methods are required to bridge this gap during early formulation develop...
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#1Chen Yunna (Anhui University of Chinese Medicine)H-Index: 1
#2Hu Mengru (Anhui University of Chinese Medicine)H-Index: 1
Last. Chen Weidong (Anhui University of Chinese Medicine)H-Index: 3
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Abstract The therapeutic effect of nanoparticles is limited in solid tumors, especially desmoplastic tumors, because the tumor matrix hinders the delivery of nanoparticles. As the most abundant cells in the tumor stroma, tumor-associated fibroblasts (TAFs) produce a dense extracellular matrix, which leads to higher tissue fluid pressure, thereby creating a physical barrier for nanoparticle delivery. Therefore, researchers focused on eliminating TAFs to combat desmoplastic tumors. In recent years...
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#1Tânia E. Sintra (University of Aveiro)H-Index: 15
#2Dinis O. Abranches (University of Aveiro)H-Index: 6
Last. João A. P. Coutinho (University of Aveiro)H-Index: 102
view all 6 authors...
Hydrotropy is a well-established strategy to enhance the aqueous solubility of hydrophobic drugs, facilitating their formulation for oral and dermal delivery. However, most hydrotropes studied so far possess toxicity issues and are inefficient, with large amounts being needed to achieve significant solubility increases. Inspired by recent developments in the understanding of the mechanism of hydrotropy that reveal ionic liquids as powerful hydrotropes, in the present work the use of cholinium va...
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#1Yuet Mei Khong (AbbVie)H-Index: 1
#2Jing Liu (Pfizer)H-Index: 1
Last. Arzu Selen (FDA: Food and Drug Administration)H-Index: 11
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Abstract A pediatric formulation workshop entitled “Pediatric Formulations: Challenges of Today and Strategies for Tomorrow” was held to advance pediatric drug product development efforts in both pre-competitive and competitive environments. The workshop had four main sessions discussing key considerations of Formulation, Analytical, Clinical and Regulatory. This paper focuses on the clinical session of the workshop. It provides an overview of the discussion on the interconnection of pediatric f...
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#1Ling Liang (Huada: Beijing University of Chemical Technology)H-Index: 1
#2Wen Min Fei (Peking Union Medical College)H-Index: 1
Last. Xin Dong Guo (Huada: Beijing University of Chemical Technology)H-Index: 14
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Abstract Psoriasis is a chronic inflammatory skin disease, in which the key features are epidermis hyperplasia, hyper-keratinization, leading to low drug absorption. As an approach of transdermal drug delivery, the microneedle (MN) has received increasing attentions for its painless penetration and efficient administration. In this study, we fabricated polylactic acid polymer MNs with hot-press method and established a psoriasis-like skin inflammation model in ear and dorsal skin of mice by topi...
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