European Journal of Pharmaceutics and Biopharmaceutics
Papers 5,227
1 page of 523 pages (5,227 results)
#1Wei Zhang (SPU: Shenyang Pharmaceutical University)H-Index: 20
#2Lu Chen (SPU: Shenyang Pharmaceutical University)H-Index: 3
Last. Lu Xu (SPU: Shenyang Pharmaceutical University)H-Index: 17
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Abundant existence of extracellular matrix biological hydrogels in solid tumors precludes most therapeutics to arrive at intracellular target sites, which is probably one of the threatened reasons of pancreatic ductal adenocarcinoma (PDAC) for public health. In this study, we designed a rod-shaped protocell nanoparticle loading with doxorubicin hydrochloride (Dox) and indocyanine green (ICG), denoted as Dox/ICG-RsPNs, for enhanced chemo-photothermal PDAC treatment. The enhanced therapeutic effic...
#1Nikolay P. IsaevH-Index: 7
#1Nikolay IsaevH-Index: 1
Last. Heinz-Jürgen Steinhoff (Osnabrück University)H-Index: 43
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Lyophilization can extend protein drugs stability and shelf life, but it also can lead to protein degradation in some cases. The development of safe freeze-drying approaches for sensitive proteins requires a better understanding of lyophilization on the molecular level. The evaluation of the freezing process and its impact on the protein environment in the nm scale is challenging because feasible experimental methods are scarce. In the present work we apply pulse EPR as a tool to study the local...
#1Haidara Majid (HHU: Heinrich Heine University Düsseldorf)H-Index: 2
#2Anke Bartel (HHU: Heinrich Heine University Düsseldorf)H-Index: 2
Last. Bjoern B. Burckhardt (HHU: Heinrich Heine University Düsseldorf)H-Index: 6
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Abstract null null In preclinical drug development, ex vivo and in vitro permeability studies are a decisive element for specifying subsequent development steps. In this context, reliability, physiological alignment and appropriate in vivo correlation are mandatory for predictivity regarding drug absorption. Especially in oromucosal drug delivery, these prerequisites are not adequately met, which hinders its progressive development and results in the continuous need for animal experiments. To ad...
#1M. Müller (HHU: Heinrich Heine University Düsseldorf)H-Index: 11
#2Raphael Wiedey (HHU: Heinrich Heine University Düsseldorf)H-Index: 6
Last. Jörg Breitkreutz (HHU: Heinrich Heine University Düsseldorf)H-Index: 40
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Abstract null null Poor solubility of drug candidates is a well-known and thoroughly studied challenge in the development of oral dosage forms. One important approach to tackle this challenge is the formulation as an amorphous solid dispersion (ASD). To reach the desired biopharmaceutical improvement a high supersaturation has to be reached quickly and then be conserved long enough for absorption to take place. In the presented study, various formulations of regorafenib have been produced and ch...
#1Yohann Corvis (University of Paris)H-Index: 17
#2N. Guiblin (University of Paris-Saclay)H-Index: 11
Last. Philippe Espeau (University of Paris)H-Index: 9
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Abstract null null The stable and metastable phase diagrams between the sinister and the rectus ibuprofen enantiomers were established by means of thermal analysis and X-ray powder diffraction experiments as a function of temperature. The results obtained allow proving for the first time the existence, for the stable system, of a solid solution by mixing the racemic ibuprofen with one of its enantiomers for low concentration of the enantiomer. Since the rectus ibuprofen is a non-active pharmaceu...
#1Andrew Strongrich (Purdue University West Lafayette)H-Index: 6
#2Alina Alexeenko (Purdue University West Lafayette)H-Index: 24
Abstract null null Wireless sensor networks have become prolific in a wide range of industrial processes and offer several key advantages over their wired counterparts in terms of positioning flexibility, modularity, interconnectivity, and data routing. We demonstrate their utility in pharmaceutical lyophilization by developing a series of wireless devices to measure spatial variations in gas pressure and temperature during primary drying. The influence of shelf temperature, chamber pressure, ex...
#1Helena Braet (Ghent University)H-Index: 3
#2Mohammad Rahimi-Gorji (Ghent University)H-Index: 22
Last. Wim Ceelen (Ghent University)H-Index: 46
view all 12 authors...
Abstract null null Peritoneal metastasis is an advanced cancer type which can be treated with pressurized intraperitoneal aerosol chemotherapy (PIPAC). Here, chemotherapeutics are nebulized under high pressure in the intraperitoneal (IP) cavity to obtain a better biodistribution and tumor penetration. To prevent the fast leakage of chemotherapeutics from the IP cavity, however, nebulization of controlled release formulations is of interest. null In this study, the potential of the thermosensitiv...
#1Qamar Abuhassan (Strathclyde Institute of Pharmacy and Biomedical Sciences)
#2Ibrahim Khadra (Strathclyde Institute of Pharmacy and Biomedical Sciences)H-Index: 9
Last. Gavin Halbert (Strathclyde Institute of Pharmacy and Biomedical Sciences)H-Index: 25
view all 4 authors...
Drug solubility is a key parameter controlling oral absorption, but intestinal solubility is difficult to assess in vitro. Human intestinal fluid (HIF) aspirates can be applied but they are variable, difficult to obtain and expensive. Simulated intestinal fluids (SIF) are a useful surrogate but multiple recipes are available and the optimum is unknown. A recent study characterised fasted HIF aspirates using a multi-dimensional approach and determined nine bioequivalent SIF media recipes that rep...
#1Claudia Vater (University of Vienna)H-Index: 2
#2Leonie Bosch (University of Vienna)
Last. Victoria Klang (University of Vienna)H-Index: 15
view all 10 authors...
In previous studies, lecithin-based nanoemulsions (NEs) have been shown to be skin friendly drug carrier systems. Due to their nontoxic properties, NEs might also be suitable as wound healing agents. Hence, different O/W NEs based on lecithin Lipoid® S 75 and plant oils or medium chain triglycerides were produced and characterised. Two lipophilic natural wound healing agents, a betulin-enriched extract from birch bark (BET) and a purified spruce balm (PSB), were successfully incorporated and the...
#1Monique C P Mendonça (UCC: University College Cork)H-Index: 1
#2Michael F. Cronin (UCC: University College Cork)H-Index: 6
Last. Caitriona M. O’Driscoll (UCC: University College Cork)H-Index: 38
view all 4 authors...
Huntington's disease (HD) is a neurodegenerative disorder caused by a mutation in the huntingtin (HTT) gene, leading to a toxic version of the HTT protein. There are currently no disease-modifying therapies available. In this scenario, gene-based treatments for HD aimed at lowering HTT levels have become one of the most promising emerging therapeutic options. To date, however, promising results have only been achieved following direct intrathecal or intracranial injections designed to circumvent...
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