Original paper
Spatially resolved analysis of FFPE tissue proteomes by quantitative mass spectrometry
Abstract
Bottom-up mass spectrometry-based proteomics relies on protein digestion and peptide purification. The application of such methods to broadly available clinical samples such as formalin-fixed and paraffin-embedded (FFPE) tissues requires reversal of chemical crosslinking and the removal of reagents that are incompatible with mass spectrometry. Here, we describe in detail a protocol that combines tissue disruption by ultrasonication, heat-induced...
Paper Details
Title
Spatially resolved analysis of FFPE tissue proteomes by quantitative mass spectrometry
Published Date
Jul 31, 2020
Journal
Volume
15
Issue
9
Pages
2956 - 2979
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Notes
History