Original paper
New hybrids of tacrine and indomethacin as multifunctional acetylcholinesterase inhibitors
Abstract
A new series of hybrid compounds were designed, consisting of anti-AChE and BuChE activity components with an anti-inflammatory component. A series of 9-amino-1,2,3,4-tetrahydroacridine and indomethacin derivatives were synthesized. All compounds were created using alkyldiamine with different chain lengths as a linker. Various biological activities were evaluated, including inhibitory activity against AChE and BuChE. The tested compounds showed...
Paper Details
Title
New hybrids of tacrine and indomethacin as multifunctional acetylcholinesterase inhibitors
Published Date
Jul 29, 2020
Journal
Volume
75
Issue
1
Pages
249 - 264
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Notes
History