Systematic review with meta-analysis: global prevalence of uninvestigated dyspepsia according to the Rome criteria.

Published on Sep 1, 2020in Alimentary Pharmacology & Therapeutics8.171
· DOI :10.1111/APT.16006
Brigida Barberio9
Estimated H-index: 9
(UNIPD: University of Padua),
Sanjiv Mahadeva33
Estimated H-index: 33
(UM: University of Malaya)
+ 2 AuthorsAlexander C. Ford88
Estimated H-index: 88
(University of Leeds)
Sources
Abstract
BACKGROUND Prevalence of uninvestigated dyspepsia varies across cross-sectional surveys. This may be due to differences in definitions used or study methodology, rather than global variability. AIM To determine the global prevalence of uninvestigated dyspepsia according to Rome criteria. METHODS MEDLINE and EMBASE were searched to identify population-based studies reporting prevalence of uninvestigated dyspepsia in adults (≥18 years old) according to Rome I, II, III or IV criteria. Prevalence of uninvestigated dyspepsia was extracted, according to criteria used to define it. Pooled prevalence, according to study location and certain other characteristics, odds ratios (OR), and 95% confidence intervals (CIs) were calculated. RESULTS Of 2133 citations evaluated, 67 studies fulfilled eligibility criteria, representing 98 separate populations, comprising 338 383 subjects. Pooled prevalence ranged from 17.6% (95% CI 9.8%-27.1%) in studies defining uninvestigated dyspepsia according to Rome I criteria, to 6.9% (95% CI 5.7%-8.2%) in those using Rome IV criteria. Postprandial distress syndrome was the commonest subtype, occurring in 46.2% of participants using Rome III criteria, and 62.8% with Rome IV. Prevalence of uninvestigated dyspepsia was up to 1.5-fold higher in women, irrespective of the definition used. There was significant heterogeneity between studies in all our analyses, which persisted even when the same criteria were applied and similar methodology was used. CONCLUSIONS Even when uniform symptom-based criteria are used to define the presence of uninvestigated dyspepsia, prevalence varies between countries. This suggests that there are environmental, cultural, ethnic, dietary or genetic influences determining symptoms.
📖 Papers frequently viewed together
References86
Newest
#1Florencia Carbone (Katholieke Universiteit Leuven)H-Index: 14
#2Tim Vanuytsel (Katholieke Universiteit Leuven)H-Index: 29
Last. Jan Tack (Katholieke Universiteit Leuven)H-Index: 128
view all 3 authors...
Abstract Background & Aims Among patients with functional dyspepsia (FD), there is overlap in symptoms between those in the Rome III subgroups of postprandial distress syndrome (PDS) and those with epigastric pain syndrome (EPS). The Rome IV consensus proposed to incorporate all patients with postprandial symptoms into the PDS group. We aimed to evaluate the assessment of meal-related dyspepsia symptoms in patients with FD according to the Rome III vs Rome IV subdivisions. Methods Consecutive pa...
Source
Source
#1Michael D. PotterH-Index: 10
#2Michael JonesH-Index: 102
Last. Nicholas J. TalleyH-Index: 187
view all 7 authors...
Source
#1Rapat Pittayanon (McMaster University)H-Index: 17
#2Yuhong Yuan (McMaster University)H-Index: 38
Last. Paul Moayyedi (McMaster University)H-Index: 117
view all 8 authors...
Prokinetics are recommended for the treatment of functional dyspepsia (FD) but systematic reviews give conflicting results on the efficacy of these agents. We have therefore conducted an updated systematic review to support the 2017 joint ACG/CAG dyspepsia guidelines. Electronic databases, including MEDLINE, EMBASE, and CENTRAL, were searched until September 2017 for randomized controlled trials (RCTs) comparing either prokinetics and placebo or two types of prokinetics to improve FD symptoms. T...
Source
#1Michael D. Potter (University of Newcastle)H-Index: 10
#2Marjorie M. Walker (University of Newcastle)H-Index: 65
Last. Nicholas J. Talley (University of Newcastle)H-Index: 187
view all 6 authors...
Wheat avoidance in the absence of celiac disease (CD) is common but occurrence of concurrent functional gastrointestinal disorders (FGIDs) in this group is uncertain. The aims of this study were to determine the prevalence of self-reported wheat or gluten sensitivity and doctor diagnosed CD in an Australian population, define the associated gastrointestinal (GI) symptoms and FGIDs, and determine the relationship between self-reported wheat sensitivity, demographic and medical factors. A total of...
Source
Summary Background The population prevalence, clinical characteristics, and associations for Rome IV functional dyspepsia are not known. Following the publication of the Rome IV criteria for functional gastrointestinal disorders, we aimed to assess the prevalence, characteristics, and associations for symptom-based Rome IV functional dyspepsia in adults across the USA, Canada, and the UK. Methods We sent an internet-based cross-sectional health survey to adults in the general population of three...
Source
#1Ji-Hao Xu (SYSU: Sun Yat-sen University)H-Index: 9
#2Yu Lai (SYSU: Sun Yat-sen University)H-Index: 5
Last. Tao Yu (SYSU: Sun Yat-sen University)H-Index: 16
view all 7 authors...
: BACKGROUND Functional dyspepsia (FD) refers to a group of upper gastrointestinal syndromes, subdivided into two types: postprandial distress syndrome (PDS) and epigastric pain syndrome (EPS). The etiology of FD remains unclear; however, unhealthy dietary habit is one potential underlying cause. We aim to explore the association of poor dietary habits with FD and its subtypes. MATERIAL AND METHODS A validated epidemiological questionnaire was designed to investigate dietary habits and gastroint...
Source
#1Max Schmulson (UNAM: National Autonomous University of Mexico)H-Index: 27
#2Douglas A. Drossman (UNC: University of North Carolina at Chapel Hill)H-Index: 101
: Functional gastrointestinal disorders (FGIDs) are diagnosed and classified using the Rome criteria; the criteria may change over time as new scientific data emerge. The Rome IV was released in May 2016. The aim is to review the main changes in Rome IV. FGIDs are now called disorders of gut-brain interaction (DGBI). Rome IV has a multicultural rather than a Western-culture focus. There are new chapters including multicultural, age-gender-women's health, intestinal microenvironment, biopsychosoc...
Source
Background and Aim As best estimates on functional gastrointestinal disorders (FGIDs) prevalence are expected from community studies, which are scanty from Asia, we evaluated the prevalence and risk factors of FGIDs in a rural Indian community. Methods House-to-house survey was undertaken by trained interviewers using translated-validated Rome III and hospital anxiety and depression questionnaires. Result Among 3426 subjects ≥ 18 years old from 3 villages in Uttar Pradesh, 84% participated, of w...
Source
CONTEXTO Tem sido relatado que cerca de 15% a 40% da populacao geral apresenta alguma queixa dispeptica e/ou pirose. Os sintomas dispepticos podem surgir em qualquer idade e sao mais prevalentes no sexo feminino. OBJETIVO Investigar a prevalencia de sintomas dispepticos e pirose em individuos com idade superior a 18 anos. METODOS Foram selecionados aleatoriamente individuos com idade superior a 18 anos, entrevistados em pracas publicas de Belo Horizonte/MG, por meio de um questionario que abordo...
Source
Cited By9
Newest
#1Mudar Zand Irani (University of Newcastle)H-Index: 1
#2Michael Jones (Macquarie University)H-Index: 102
Last. Nicholas J. Talley (University of Newcastle)H-Index: 187
view all 9 authors...
Background null Rumination syndrome is a functional gastroduodenal disorder characterised by effortless regurgitation of recently ingested food. Emerging evidence reports duodenal eosinophilic inflammation in a subset, suggesting a shared pathophysiology with functional dyspepsia (FD). null Aim null To assess the clinical features of rumination syndrome and FD in a community-based study. null Methods null We mailed a survey assessing gastrointestinal symptoms, diet and psychological symptoms to ...
Source
#1Eskelinen MH-Index: 16
#2Jannica MeklinH-Index: 2
Last. Matti EskelinenH-Index: 23
view all 5 authors...
Source
#1Brigida Barberio (UNIPD: University of Padua)H-Index: 9
#2Ciaran Judge (St James's University Hospital)H-Index: 1
Last. Alexander C. Ford (University of Leeds)H-Index: 88
view all 4 authors...
Summary null Background null Functional constipation is a common functional bowel disorder in the community, which has a varying prevalence across cross-sectional surveys. We did a contemporaneous systematic review and meta-analysis of studies using comparable methodology and all iterations of the Rome criteria to estimate the global prevalence of functional constipation. null Methods null In this systematic review and meta-analysis, we searched MEDLINE, Embase, and Embase Classic from Jan 1, 19...
Source
#1Brigida Barberio (UNIPD: University of Padua)H-Index: 9
#2Yan Yiannakou (County Durham and Darlington NHS Foundation Trust)H-Index: 15
Last. Alexander C. Ford (University of Leeds)H-Index: 88
view all 6 authors...
ABSTRACT Objectives Disorders of gut-brain interaction, such as irritable bowel syndrome (IBS) and functional dyspepsia (FD) frequently overlap, but the impact of this on the natural history is unknown. We examined this issue in a longitudinal follow-up study conducted in a large cohort of individuals. Methods We collected complete demographic, symptom, mood, and psychological health data from 1374 adults who self-identified as having IBS. We applied the Rome IV criteria to examine what proporti...
Source
#1Brigida Barberio (UNIPD: University of Padua)H-Index: 9
#2Ciaran Judge (St James's University Hospital)H-Index: 1
Last. Alexander C. Ford (University of Leeds)H-Index: 88
view all 4 authors...
Background: Chronic idiopathic constipation (CIC) is a common functional bowel disorder in the community, whose prevalence varies across cross-sectional surveys. We performed a contemporaneous systematic review of studies using comparable methodology, and all iterations of the Rome criteria, to estimate global prevalence. Methods: MEDLINE, EMBASE, and EMBASE Classic were searched (from 1990 to December 2020) to identify population-based studies reporting the prevalence of CIC in adults (≥18 year...
Source
#1Brigida Barberio (UNIPD: University of Padua)H-Index: 9
#2Christopher J Black (St James's University Hospital)H-Index: 15
Last. Alexander C. Ford (St James's University Hospital)H-Index: 88
view all 3 authors...
Source
Background Functional dyspepsia (FD) is a common and frequently-occurring disease in internal medicine. It is known that Liujunzi decoction and acupuncture are widely used in the treatment of FD, but there are few studies on the combination of Liujunzi decoction and acupuncture in the treatment of FD, and its safety and efficacy are still controversial. Therefore, the purpose of this study is to evaluate the efficacy and safety of acupuncture combined with Liujunzi decoction in the treatment of ...
Source
#1Chen Li (Fourth Military Medical University)H-Index: 11
#2Junrong Xu (Northwest University (United States))H-Index: 1
Last. Lei Shang (Fourth Military Medical University)H-Index: 6
view all 7 authors...
Functional gastrointestinal disorders (FGIDs) are common among the aircrew due to their arduous working environment. This study investigated the prevalence of FGIDs in Chinese male pilots and assessed the effects of trigger factors on the FGIDs. A cross-sectional study including 212 male pilots was performed in a Chinese large civil airline company. FGIDs were diagnosed according to the Rome IV diagnostic criteria. The psychological performance, dietary pattern, sleep situation, and physical act...
Source
#1Brigida Barberio (UNIPD: University of Padua)H-Index: 9
#2Maria Ines Pinto-Sanchez (McMaster University)H-Index: 14
Last. Alexander C. Ford (University of Leeds)H-Index: 88
view all 8 authors...
Background Conventionally, patients with functional dyspepsia are subgrouped based on upper gastrointestinal symptoms, according to the Rome criteria. However, psychological co-morbidity and extraintestinal symptoms are also relevant to functional gastrointestinal disorders. Aim To investigate whether it is possible to subgroup people with functional dyspepsia using factors beyond upper gastrointestinal symptoms. Methods We collected demographic, symptom and psychological health data from adult ...
Source
#1Michael D. Potter (University of Newcastle)H-Index: 10
#2Nicholas J. Talley (University of Newcastle)H-Index: 187
Source
This website uses cookies.
We use cookies to improve your online experience. By continuing to use our website we assume you agree to the placement of these cookies.
To learn more, you can find in our Privacy Policy.