Intestinal estrogen receptor beta suppresses colon inflammation and tumorigenesis in both sexes

Volume: 492, Pages: 54 - 62
Published: Nov 1, 2020
Abstract
Estrogen hormones protect against colorectal cancer (CRC) and a preventative role of estrogen receptor beta (ERβ) on CRC has been supported using full knockout animals. However, it is unclear through which cells or organ ERβ mediates this effect. To investigate the functional role of intestinal ERβ during colitis-associated CRC we used intestine-specific ERβ knockout mice treated with azoxymethane and dextran sodium sulfate, followed by ex vivo...
Paper Details
Title
Intestinal estrogen receptor beta suppresses colon inflammation and tumorigenesis in both sexes
Published Date
Nov 1, 2020
Volume
492
Pages
54 - 62
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