Long-term outcomes of refractory Takayasu arteritis patients treated with biologics including ustekinumab

Published on May 4, 2021in Modern Rheumatology2.113
· DOI :10.1080/14397595.2020.1800560
Yoshie Gon2
Estimated H-index: 2
(Kyoto University),
Hajime Yoshifuji24
Estimated H-index: 24
(Kyoto University)
+ 5 AuthorsChikashi Terao32
Estimated H-index: 32
(Kyoto University)
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Abstract
Objectives: Biologics have been used to treat refractory Takayasu arteritis (TAK), but their efficacy and safety have not been sufficiently evaluated.Methods: We extracted clinical information from...
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#1Chikashi Terao (Kyoto University)H-Index: 32
#2Hajime Yoshifuji (Kyoto University)H-Index: 24
Last. Fumihiko Matsuda (Kyoto University)H-Index: 75
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Takayasu arteritis (TAK) is a systemic vasculitis with severe complications that affects the aorta and its large branches. HLA-B*52 is an established susceptibility locus to TAK. To date, there are still only a limited number of reports concerning non-HLA susceptibility loci to TAK. We conducted a genome-wide association study (GWAS) and a follow-up study in a total of 633 TAK cases and 5,928 controls. A total of 510,879 SNPs were genotyped, and 5,875,450 SNPs were imputed together with HLA-B*52...
22 CitationsSource
#1Yoshikazu NakaokaH-Index: 24
#2Mitsuaki Isobe (Tokyo Medical and Dental University)H-Index: 70
Last. Norihiro Nishimoto (TMU: Tokyo Medical University)H-Index: 66
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Objective To investigate the efficacy and safety of the interleukin-6 receptor antibody tocilizumab in patients with Takayasu arteritis (TAK). Methods Patients with TAK who had relapsed within the previous 12 weeks were induced into remission with oral glucocorticoid therapy. In this double-blind, placebo-controlled trial, patients were randomly assigned 1:1 to receive weekly tocilizumab 162 mg or placebo subcutaneously, and oral glucocorticoids were tapered 10 %/week from week 4 to a minimum of...
125 CitationsSource
#1Toshiki Nakajima (Kyoto University)H-Index: 7
#2Hajime Yoshifuji (Kyoto University)H-Index: 24
Last. Tsuneyo Mimori (Kyoto University)H-Index: 77
view all 12 authors...
Background A previous study revealed the association between susceptibility to Takayasu arteritis (TAK) and a single nucleotide polymorphism (SNP) rs6871626 located in IL12B, which encodes interleukin (IL)-12p40, a common component of IL-12p70 and IL-23. We investigated the expression of these cytokines in patients with TAK, stratifying them into those with or without the risk allele at the rs6871626 SNP.
13 CitationsSource
#1Chikashi Terao (Kyoto University)H-Index: 32
#2Hajime Yoshifuji (Kyoto University)H-Index: 24
Last. Tsuneyo Mimori (Kyoto University)H-Index: 77
view all 6 authors...
Takayasu arteritis (TAK) is a systemic vasculitis affecting the large arteries (1). Glucocorticoids and immunosuppressants including biological agents targeting tumour necrosis factor (TNF)-α and t...
38 CitationsSource
#1Yoshiko Watanabe (Kawasaki Medical School)H-Index: 6
#2Tetsuro MiyataH-Index: 29
Last. Kazuo Tanemoto (Kawasaki Medical School)H-Index: 24
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Background —The clinical features of newly diagnosed Japanese patients with Takayasu arteritis (TA) and its age or sex specificities are unknown. Methods and Results —We analyzed information from nationwide registration forms submitted by TA patients between April 2001 and March 2011, as part of a research program by the Japanese Ministry of Health, Labour and Welfare. Among the 7779 patients who submitted their forms, 1372 newly registered TA patients were enrolled consisting of 83.8% female pa...
83 CitationsSource
#1Arsène MekinianH-Index: 41
#2Cloé Comarmond (University of Paris)H-Index: 23
Last. David Saadoun (University of Paris)H-Index: 73
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Background —To assess safety and efficacy of biologics (i.e. TNF-α antagonists and tocilizumab) in patients with Takayasu arteritis (TA). Methods and Results —Retrospective multicenter study of characteristics and outcome of 49 TA patients [80% of females; median age 42 [20-55] years] treated by TNF-α antagonists (80%) or tocilizumab (20%)] and fulfilling ACR and/or Ishikawa criteria. Factors associated with complete response were assessed. Eighty-eight percent of TA patients were inadequately c...
94 CitationsSource
#1David Saadoun (UPMC: Pierre-and-Marie-Curie University)H-Index: 73
#2Marlène Garrido (UPMC: Pierre-and-Marie-Curie University)H-Index: 4
Last. Patrice Cacoub (UPMC: Pierre-and-Marie-Curie University)H-Index: 122
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Objective Takayasu arteritis (TAK) is a large-vessel vasculitis that induces damage to the aorta and its branches. Glucocorticoids remain the gold standard of therapy for TAK. The nature of the T cells driving vascular inflammation and the effects of glucocorticoids on the systemic components of TAK are not understood. The aim of this study was to analyze T cell homeostasis and cytokine production in peripheral blood and inflammatory lesions of the aorta in patients with TAK. Methods T cell home...
108 CitationsSource
#1Chikashi Terao (Kyoto University)H-Index: 32
#2Takayoshi Matsumura (UTokyo: University of Tokyo)H-Index: 16
Last. Fumihiko MatsudaH-Index: 75
view all 34 authors...
Objective Takayasu arteritis (TAK) is a systemic vasculitis affecting large arteries and large branches of the aorta. Ulcerative colitis (UC) is a prevalent autoimmune colitis. Since TAK and UC share HLA–B*52:01 and IL12B as genetic determinants, and since there are case reports of the co-occurrence of these diseases, we hypothesized that UC is a common complication of TAK. We undertook this study to perform a large-scale analysis of TAK, both to evaluate the prevalence of concurrent cases of TA...
65 CitationsSource
#1Noémie Abisror (University of Paris)H-Index: 7
#2Arsène Mekinian (University of Paris)H-Index: 41
Last. Snfmi (University of Paris)H-Index: 4
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Abstract Background/purpose The aim of this study is to analyze the efficacy and tolerance of tocilizumab in patients with Takayasu arteritis (TA). Methods We retrospectively studied patients with TA (ACR and/or Ishikawa's criteria): 5 French multicenter cases and 39 from the literature. Clinical, biological, radiological disease activity and treatment were analyzed before tocilizumab, during the follow-up and at the last available visit. Results Forty-four patients (median age 26 years [3–65];)...
86 CitationsSource
#1Chikashi Terao (Kyoto University)H-Index: 32
#2Hajime Yoshifuji (Kyoto University)H-Index: 24
Last. Fumihiko Matsuda (Kyoto University)H-Index: 75
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Takayasu arteritis (TAK) is an autoimmune systemic vasculitis of unknown etiology. Although previous studies have revealed that HLA-B∗52:01 has an effect on TAK susceptibility, no other genetic determinants have been established so far. Here, we performed genome scanning of 167 TAK cases and 663 healthy controls via Illumina Infinium Human Exome BeadChip arrays, followed by a replication study consisting of 212 TAK cases and 1,322 controls. As a result, we found that the IL12B region on chromoso...
89 CitationsSource
Cited By3
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#1Durga Prasanna Misra (SGPGIMS: Sanjay Gandhi Post Graduate Institute of Medical Sciences)H-Index: 15
#2Upendra Rathore (SGPGIMS: Sanjay Gandhi Post Graduate Institute of Medical Sciences)H-Index: 2
Last. Aman Sharma (PGIMER: Post Graduate Institute of Medical Education and Research)H-Index: 30
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The pharmacotherapy of Takayasu arteritis (TAK) with disease-modifying anti-rheumatic drugs (DMARDs) is an evolving area. A systematic review of Scopus, Web of Science, Pubmed Central, clinical trial databases and recent international rheumatology conferences for interventional and observational studies reporting the effectiveness of DMARDs in TAK identified four randomized controlled trials (RCTs, with another longer-term follow-up of one RCT) and 63 observational studies. The identified trials...
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#1Tsuyoshi Shirai (Tohoku University)H-Index: 12
#2Hiroshi Sato (Tohoku University)H-Index: 39
Last. Hideo Harigae (Tohoku University)H-Index: 33
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Objective: Although biologic agents are used in Takayasu arteritis (TAK), corticosteroids are still the mainstay of treatment. This study aimed to investigate the feasible maintenance dose of prednisolone (PSL) in the biologic therapy era.Method: We enrolled 93 patients with TAK who satisfied the criteria of the American College of Rheumatology and visited our department from 2008 to 2018. The clinical characteristics and PSL dose of the patients were retrospectively evaluated.Results: The mean ...
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