Mesenchymal Stem Cell Immunomodulation: Mechanisms and Therapeutic Potential

MSCs are multipotent cells that are emerging as the most promising means of allogeneic cell therapy. MSCs participate in both innate and adaptive immunity, and their immunomodulatory functions are exerted mainly via interactions with immune cells through cell-to-cell contact and paracrine activity. Engineering MSCs to express specific immunomodulatory agents contributes to MSC capacity and pluripotency, and also enables them to deliver large...