Doxycycline decreases amyloidogenic light chain-induced autophagy in isolated primary cardiac myocytes

Published on Dec 15, 2020in International Journal of Cardiology3.229
· DOI :10.1016/J.IJCARD.2020.07.016
María Valero-Muñoz12
Estimated H-index: 12
(BU: Boston University),
Richard M. Wilson11
Estimated H-index: 11
(BU: Boston University)
+ 3 AuthorsFlora Sam37
Estimated H-index: 37
(BU: Boston University)
Abstract Background Immunoglobulin light chain (AL) cardiac amyloidosis is characterized by extracellular deposition of amyloid fibrils in the heart and is potentially fatal. Untreated, it manifests clinically as heart failure with a precipitous decline and a median survival of Methods/results Adult rat ventricular myocytes stimulated with AL (obtained from cardiac amyloidosis patients) increased MMP-2 and MMP-9 activities (P  Conclusions These in vitro studies demonstrated that doxycycline, in addition to inhibiting MMP, also modulated AL-induced autophagy in cardiomyocytes and provide potential insights for future therapeutic targets for AL-induced proteotoxicity. Novel therapies for cardiotoxicity and heart failure in AL cardiac amyloidosis remain an important unmet need.
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