Randomised clinical trial: oesophageal radiofrequency energy delivery versus sham for PPI‐refractory heartburn

Summary Background Oesophageal radiofrequency reduces use of proton pump inhibitors (PPIs) in patients with gastro‐oesophageal reflux disease responding to PPIs. Aim To determine the efficacy of oesophageal radiofrequency in patients with PPI‐refractory heartburn. Methods A randomised, double‐blind, sham‐controlled multicentre study was designed to assess the efficacy of oesophageal radiofrequency in PPI non‐responding patients with heartburn....