Target recognition and network pharmacology for revealing anti-diabetes mechanisms of natural product

Diabetes is a metabolic disease characterized by persistent hyperglycemia, which results in serious complications such as cardiovascular disorder, neuropathy, renal failure, and retinopathy. Various anti-diabetic drugs have been developed, however, their therapeutic effect is far from satisfactory. Therefore, increasing attention has been paid to natural products, whose multi-targets characteristics might contribute to treating polygenetic...