Internal medicine

Endocrinology

Oxidative stress

Inflammation

Hyperuricemia

Uric acid

Kidney

Gout

Febuxostat

Endothelial dysfunction

Renal injury

Bioinformatics

Medicine

Biology

BioMed Research International

Uric acid is the end product of purine metabolism in humans, and its excessive accumulation leads to hyperuricemia and urate crystal deposition in tissues including joints and kidneys. Hyperuricemia is considered an independent risk factor for cardiovascular and renal diseases. Although the symptoms of hyperuricemia-induced renal injury have long been known, the pathophysiological molecular mechanisms are not completely understood. In this review, we focus on the research advances in the mechanisms of hyperuricemia-caused renal injury, primarily on oxidative stress, endothelial dysfunction, renal fibrosis, and inflammation. Furthermore, we discuss the progress in hyperuricemia management.

Research Advances in the Mechanisms of Hyperuricemia-Induced Renal Injury