Coronavirus

Immune dysregulation

2019-20 coronavirus outbreak

Biology

Virology

Signal transduction

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

Outbreak

Coronavirus disease 2019 (COVID-19)

Immunology

Genetics

Immune system

Cytokine

Infectious disease (medical specialty)

Internal medicine

Medicine

Pneumonia

Disease

Journal of Clinical Investigation

BACKGROUND. Patients with coronavirus disease 2019 (COVID-19) develop pneumonia generally associated with lymphopenia and a severe inflammatory response due to uncontrolled cytokine release. These mediators are transcriptionally regulated by the JAK/STAT signaling pathways, which can be disabled by small molecules.

Baricitinib restrains the immune dysregulation in patients with severe COVID-19