Photodynamic Therapy and Immune Checkpoint Blockade

Published on Jun 23, 2020in Photochemistry and Photobiology3.421
路 DOI :10.1111/PHP.13300
Gwendolyn M. Cramer6
Estimated H-index: 6
(UPenn: University of Pennsylvania),
Edmund K. Moon24
Estimated H-index: 24
(UPenn: University of Pennsylvania)
+ 1 AuthorsTheresa M. Busch32
Estimated H-index: 32
(UPenn: University of Pennsylvania)
Sources
Abstract
Immune checkpoints including PD-1 and CTLA-4 help to regulate the intensity and timeframe of the immune response. Since they become upregulated in cancer and prevent sufficient anti-tumor immunity, monoclonal antibodies against these checkpoints have shown clinical promise for a range of cancers. Multimodal treatment plans combining immune checkpoint inhibitors with other therapies, including photodynamic therapy (PDT), may help to expand treatment efficacy and minimize side effects. PDT's cytotoxic effects are spatially limited by the light activation process, constraining PDT direct effects to the treatment field. The production of damage-associated molecular patterns and tumor-associated antigens from PDT can encourage accumulation and maturation of antigen presenting cells and reprogram the tumor microenvironment to be more susceptible to therapies targeting immune checkpoints.
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References61
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#1Hu Liqin (MOE: Chinese Ministry of Education)H-Index: 2
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#1Rui Zhang (CityU: City University of Hong Kong)H-Index: 15
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#1Shubhankar Nath (Harvard University)H-Index: 7
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#1Andrew M. Davis (NU: Northwestern University)H-Index: 91
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#2Fan Zhang (JLU: Jilin University)H-Index: 17
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: Inflammatory cells, most especially neutrophils, can be a necessary component of the antitumor activity occurring after administration of photodynamic therapy. Generation of neutrophil responses has been suggested to be particularly important in instances when the delivered photodynamic therapy (PDT) dose is insufficient. In these cases, the release of neutrophil granules and engagement of antitumor immunity may play an important role in eliminating residual disease. Herein, we utilize in聽vivo...
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