Physics

Internal medicine

Pathology

Placebo

Incidence (geometry)

Biology

Optics

Cancer

Obstetrics

Surgery

Randomized controlled trial

Alternative medicine

Cervix

Twin Pregnancy

Gynecology

Pregnancy

Gestation

Genetics

Medicine

American Journal of Obstetrics and Gynecology

In women with a singleton pregnancy and sonographic short cervix in midgestation, vaginal administration of progesterone reduces the risk of early preterm birth and improves neonatal outcomes without any demonstrable deleterious effects on childhood neurodevelopment. In women with twin pregnancies, the rate of spontaneous early preterm birth is 10 times higher than that in singletons, and in this respect, all twins are at an increased risk of preterm birth. However, 6 trials in unselected twin pregnancies reported that vaginal administration of progesterone from midgestation had no significant effect on the incidence of early preterm birth.

Early vaginal progesterone versus placebo in twin pregnancies for the prevention of spontaneous preterm birth: a randomized, double-blind trial