Original paper

Salt causes aging-associated hypertension via vascular Wnt5a under Klotho deficiency

Published: Jun 29, 2020
Abstract
Aging is associated with a high prevalence of hypertension due to elevated susceptibility of BP to dietary salt, but its mechanism is unknown. Serum levels of Klotho, an anti-aging factor, decline with age. We found that high salt (HS) increased BP in aged mice and young heterozygous Klotho-knockout mice and was associated with increased vascular expression of Wnt5a and p-MYPT1, which indicate RhoA activity. Not only the Wnt inhibitor LGK974 and...
Paper Details
Title
Salt causes aging-associated hypertension via vascular Wnt5a under Klotho deficiency
Published Date
Jun 29, 2020
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