Senolytic CAR T cells reverse senescence-associated pathologies

Nature64.80
Volume: 583, Issue: 7814, Pages: 127 - 132
Published: Jun 17, 2020
Abstract
Cellular senescence is characterized by stable cell-cycle arrest and a secretory program that modulates the tissue microenvironment1,2. Physiologically, senescence serves as a tumour-suppressive mechanism that prevents the expansion of premalignant cells3,4 and has a beneficial role in wound-healing responses5,6. Pathologically, the aberrant accumulation of senescent cells generates an inflammatory milieu that leads to chronic tissue damage and...
Paper Details
Title
Senolytic CAR T cells reverse senescence-associated pathologies
Published Date
Jun 17, 2020
Journal
Volume
583
Issue
7814
Pages
127 - 132
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