Review paper
Dissecting the heritable risk of breast cancer: From statistical methods to susceptibility genes
Abstract
Decades of research have shown that rare highly penetrant mutations can promote tumorigenesis, but it is still unclear whether variants observed at high-frequency in the broader population could modulate the risk of developing cancer. Genome-wide Association Studies (GWAS) have generated a wealth of data linking single nucleotide polymorphisms (SNPs) to increased cancer risk, but the effect of these mutations are usually subtle, leaving most of...
Paper Details
Title
Dissecting the heritable risk of breast cancer: From statistical methods to susceptibility genes
Published Date
Jul 1, 2021
Journal
Volume
72
Pages
175 - 184
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