Novel targets and therapeutic strategies for the treatment of hepatocellular carcinoma (HCC)

Liver cancer is a leading cause of cancer-related mortality worldwide and accounts for more than 800.000 deaths per year. Hepatocellular carcinoma (HCC) is a common cancer with high lethality, which is diagnosed most often at advanced stages when surgical or local treatment options are not possible. For the treatment of advanced HCC, sorafenib has been the only approved systemic treatment for nearly 10 years. Lately however, a number of...