Altered Gut Archaea Composition and Interaction With Bacteria Are Associated With Colorectal Cancer

Background & AimsChanges in the intestinal microbiota have been associated with development and progression of colorectal cancer (CRC). Archaea are stable components of the microbiota, but little is known about their composition or contribution to colorectal carcinogenesis. We analyzed archaea in fecal microbiomes of 2 large cohorts of patients with CRC.MethodsWe performed shotgun metagenomic analyses of fecal samples from 585 participants (184...