Ex vivo and in vitro evaluation of the influence of the inhaler device and formulation on lung deposition of budesonide
Abstract
Two different types of dry powder inhalers (Easyhaler® and RS01®) were used in this work to evaluate the ex vivo and in vitro performance of a budesonide inhaled formulation with recrystallised mannitol, commercial DPI-grade mannitol, or lactose. The aerodynamic performance of the budesonide formulation with recrystallised mannitol was superior when RS01® was used (FPF = 45.8%) compared to Easyhaler® (FPF = 14%). However, the aerodynamic profile...
Paper Details
Title
Ex vivo and in vitro evaluation of the influence of the inhaler device and formulation on lung deposition of budesonide
Published Date
Jul 1, 2020
Journal
Volume
372
Pages
685 - 693
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