Global Frequencies of Clinically Important HLA Alleles and Their Implications For the Cost‐Effectiveness of Preemptive Pharmacogenetic Testing

Immune‐mediated drug hypersensitivity reactions are an important source of iatrogenic morbidity and mortality. Human leukocyte antigen ( HLA ) ‐B*57:01 , HLA‐B*15:02 , HLA‐A*31:01 , and HLA‐B*58:01 constitute established risk factors and preemptive genotyping of these HLA alleles in patients prior to the initiation of abacavir, carbamazepine, and allopurinol‐based therapies can prevent toxicity and improve patient outcomes. However, the...