Stochastic non-enzymatic modification of long-lived macromolecules - A missing hallmark of aging
Abstract
Damage accumulation in long-living macromolecules (especially extracellular matrix (ECM) proteins, nuclear pore complex (NPC) proteins, and histones) is a missing hallmark of aging. Stochastic non-enzymatic modifications of ECM trigger cellular senescence as well as many other hallmarks of aging affect organ barriers integrity and drive tissue fibrosis. The importance of it for aging makes it a key target for interventions. The most promising of...
Paper Details
Title
Stochastic non-enzymatic modification of long-lived macromolecules - A missing hallmark of aging
Published Date
Sep 1, 2020
Journal
Volume
62
Pages
101097 - 101097
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