Cell biology

Algorithm

Neuroscience

Biology

Hibernation (computing)

Endocrinology

Computer science

Torpor

Environmental health

Physiology

Thermoregulation

Population

Internal medicine

Medicine

Hypothermia

State (computer science)

Nature

Hibernating mammals actively lower their body temperature to reduce energy expenditure when facing food scarcity1. This ability to induce a hypometabolic state has evoked great interest owing to its potential medical benefits2,3. Here we show that a hypothalamic neuronal circuit in rodents induces a long-lasting hypothermic and hypometabolic state similar to hibernation. In this state, although body temperature and levels of oxygen consumption are kept very low, the ability to regulate metabolism still remains functional, as in hibernation4. There was no obvious damage to tissues and organs or abnormalities in behaviour after recovery from this state. Our findings could enable the development of a method to induce a hibernation-like state, which would have potential applications in non-hibernating mammalian species including humans. In rodents, activation of a population of neurons characterized by the expression of the neuropeptide QRFP induces a hibernation-like state of long-lasting hypothermia and hypometabolism.

A discrete neuronal circuit induces a hibernation-like state in rodents