Effect of uric acid levels on mortality in Japanese peritoneal dialysis patients.

Published on May 1, 2021in Peritoneal Dialysis International1.756
· DOI :10.1177/0896860820929476
Naoki Sugano8
Estimated H-index: 8
(Jikei University School of Medicine),
Yukio Maruyama19
Estimated H-index: 19
(Jikei University School of Medicine)
+ 5 AuthorsKosaku Nitta61
Estimated H-index: 61
Sources
Abstract
Background:Unlike the situation in the general population, most studies of patients receiving hemodialysis have reported lower uric acid (UA) as associated with higher mortality. However, the relat...
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8 Authors (Ming Li, ..., Tanqi Lou)
References38
Newest
#1Shilong Xiang (ZJU: Zhejiang University)H-Index: 7
#2Xiaohui Zhang (ZJU: Zhejiang University)H-Index: 9
Last. Jianghua Chen (ZJU: Zhejiang University)H-Index: 39
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The results remain controversial with regards to the impact of serum uric acid on clinical outcomes from peritoneal dialysis population. The aim of our study was to investigate the influence of serum uric acid levels on mortality in peritoneal dialysis patients. Data on 9405 peritoneal dialysis patients from the Zhejiang Renal Data system were retrospectively analyzed. All demographic and laboratory data were recorded at baseline. The study cohort was divided into quintiles according to baseline...
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#1Naoki Sugano (Jikei University School of Medicine)H-Index: 8
#2Yukio Maruyama (Jikei University School of Medicine)H-Index: 19
Last. Takashi Yokoo (Jikei University School of Medicine)H-Index: 27
view all 8 authors...
Whether higher serum uric acid (UA) values comprise a risk factor for death and whether treatment for high UA is effective in patients undergoing hemodialysis (HD) are essentially unknown. To determine associations between UA and all-cause or cardiovascular (CV) mortality, interactions between UA or medication and effects on mortality, and significance of treatment for hyperuricemia in patients undergoing hemodialysis (HD). We collected the baseline data of 222,434 patients undergoing three HD s...
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#1Wenxiu Chang (Tianjin First Center Hospital)H-Index: 3
#2Wenyu Zhang (Tianjin First Center Hospital)H-Index: 3
Last. Shunya Uchida (Teikyo University)H-Index: 1
view all 7 authors...
BACKGROUND: Time-averaged uric acid (TA-UA) value was calculated to investigate the association of longitudinal UA and all-cause mortality in incident peritoneal dialysis (PD) patients. METHODS: Three hundred PD patients were divided into 3 groups based on the serum TA-UA level (Group 1: < 6 mg/dL; Group 2: 6-8 mg/dL; Group 3: ≥8 mg/dL). Hazards ratio (HR) of all-cause mortality was calculated. Logistic regression was conducted to identify the associated clinical factors of lower and higher TA-U...
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#1Kuan-Ju LaiH-Index: 1
#2Chew-Teng KorH-Index: 6
Last. Yao-Peng Hsieh (CSMU: Chung Shan Medical University)H-Index: 4
view all 3 authors...
Background: The results have been inconsistent with regards to the impact of uric acid (UA) on clinical outcomes both in the general population and in patients with chronic kidney disease. The aim of this study was to study the influence of serum UA levels on mortality in patients undergoing continuous ambulatory peritoneal dialysis. Methods: Data on 492 patients from a single peritoneal dialysis unit were retrospectively analyzed. The mean age of the patients was 53.5 ± 15.3 years, with 52% bei...
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#1Wei-Cheng Tseng (Taipei Veterans General Hospital)H-Index: 4
#2Yung-Tai Chen (NYMU: National Yang-Ming University)H-Index: 21
Last. Der-Cherng Tarng (Taipei Veterans General Hospital)H-Index: 8
view all 5 authors...
Background The link between elevated serum uric acid (SUA) levels and cardiovascular disease (CVD)–related mortality in the elderly population remains inconclusive. Nutritional status influences both SUA and CVD outcomes. Therefore, we investigated whether SUA‐predicted mortality and the effect‐modifying roles of malnourishment in older people. Methods and Results A longitudinal Taiwanese cohort including 127 771 adults 65 years and older participating in the Taipei City Elderly Health Examinati...
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#1Markus Bredemeier (Grupo México)H-Index: 21
#2Lediane Moreira Lopes (Grupo México)H-Index: 1
Last. Guilherme Gomes Dias Campos (Grupo México)H-Index: 2
view all 9 authors...
Xanthine oxidase inhibitors (XOI), classified as purine-like (allopurinol and oxypurinol) and non-purine (febuxostat and topiroxostat) XOI, present antioxidant properties by reducing the production of reactive oxygen species derived from purine metabolism. Oxidative stress is an important factor related to endothelial dysfunction and ischemia-reperfusion injury, and may be implicated in the pathogenesis of heart failure, hypertension, and ischemic heart disease. However, there is contradictory e...
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#1Takeo Ishii (YCU: Yokohama City University)H-Index: 3
#2Masataka Taguri (YCU: Yokohama City University)H-Index: 35
Last. Kunio OyamaH-Index: 2
view all 4 authors...
A lower serum uric acid (UA) level has been associated with a higher mortality rate in haemodialysis patients. We investigated the long-term confounding factors of UA and mortality, and fitted a marginal structural model (MSM) based on the causal effect of xanthine oxidoreductase inhibitors (XORi). In total, 2429 patients on regular dialysis from April 2013 to March 2016 were included, and divided into quintiles by serum UA with Kaplan Meier (KM) curves and log rank analysis. Baseline characteri...
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#1Christina Park (UCI: University of California, Irvine)H-Index: 7
#2Yoshitsugu Obi (UCI: University of California, Irvine)H-Index: 29
Last. Kamyar Kalantar-Zadeh (UCLA: University of California, Los Angeles)H-Index: 139
view all 8 authors...
Author(s): Park, C; Obi, Y; Streja, E; Rhee, CM; Catabay, CJ; Vaziri, ND; Kovesdy, CP; Kalantar-Zadeh, K | Abstract: The association between serum uric acid (SUA) and mortality has been conflicting among studies using hemodialysis (HD) patients. Given the close link between purine and protein in foods, we hypothesized that normalized protein catabolic rate (nPCR), a dietary protein intake surrogate, modifies the SUA-mortality association in the HD population.We identified 4298 patients who initi...
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#1Yao-Peng HsiehH-Index: 8
#2Yu Yang (CSMU: Chung Shan Medical University)H-Index: 4
Last. Chi-Chen Lin (NCHU: National Chung Hsing University)H-Index: 24
view all 7 authors...
Abstract There is little information on the relationship between uric acid (UA) and residual renal function (RRF) in continuous ambulatory peritoneal dialysis (CAPD). The aim of this research is to study the influence of UA on RRF decline in CAPD patients. A retrospective observational cohort study of 304 patients who started CAPD without anuria between 2001 and 2010 was conducted at a single medical center. The outcomes measured in the study included the rate of RRF decline and anuria. A multip...
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Background and objectives We hypothesized that longitudinal changes in uric acid (UA) may have independent associations with changes in nutritional parameters over time and consequently, long-term survival of patients on maintenance hemodialysis. Design, setting, participants, & measurements We conducted a retrospective, longitudinal cohort study of a clinical database containing the medical records of patients on maintenance hemodialysis receiving dialysis between June of 1999 and December of 2...
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Cited By4
Newest
#1Shizhu Zhao (Soochow University (Suzhou))
#2Jing-Yuan Cao (Nantong University)
Last. Guoyuan Lu (Soochow University (Suzhou))H-Index: 10
view all 7 authors...
BACKGROUND Peritoneal dialysis (PD) patients experience accelerated arterial aging, which is characterized by elastin degradation. Elastin-derived peptides (EDPs) are direct products of elastin fragmentation. This study tried to explore the association between serum EDPs and abdominal aortic calcification (AAC) in PD patients. METHODS Serum levels of EDPs were analyzed in 126 eligible PD patients and 30 controls. PD patients were grouped according to the annularity of AAC evaluated by an abdomin...
Source
#1Zhiqiang Liu (Fujian Medical University)H-Index: 5
#2Zhi-wen Huang (Fujian Medical University)
Last. Zhijian Hu (Fujian Medical University)H-Index: 14
view all 9 authors...
Background: Studies have shown inconsistent associations between serum uric acid (SUA) levels and mortality in peritoneal dialysis (PD) patients. We conducted this meta-analysis to determine whether SUA levels were associated with cardiovascular or all-cause mortality in PD patients. Methods: PubMed, Embase, Web of Science, the Cochrane Library, CNKI, VIP, Wanfang Database, and trial registry databases were systematically searched up to April 11, 2021. Cohort studies of SUA levels and cardiovasc...
Source
Objectives null To analyse the relationship between serum uric acid (SUA), all-cause and cardiovascular (CV) mortality in peritoneal dialysis (PD) patients to inform clinical practice and future research. null Design null A systematic review of observational studies. null Data sources null PubMed, Embase, Web of Science, the Cochrane Library, China National Knowledge Infrastructure (CNKI), SinoMed, Chinese Science and Technology Journal Database (VIP) and Wan Fang databases were searched from th...
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#1Quyen Dao Bui Quy (Cho Ray Hospital)H-Index: 1
Last. Thang Le VietH-Index: 1
view all 8 authors...
Aims: This study aims to access the predicting value of serum uric acid (UA) and high-sensitivity C reactive protein (hs-CRP) concentration on three-year cardiovascular-related mortality in patients performing continuous ambulatory peritoneal dialysis (CAPD). Methods: A total of267 CAPD patients [150 male (56.2%); mean age 48.93 ± 13.58 years] were included in our study. All patients had measured serum UA and hs-CRP concentration. A high-sensitivity particle-enhanced immunoturbidimetric assay de...
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#1Guansen Huang (Tongji University)H-Index: 1
#2Yi Wang (Tongji University)H-Index: 6
Last. Lili Sheng (Tongji University)
view all 12 authors...
The relationship between baseline high peritoneal solute transport rate (PSTR) and the prognosis of peritoneal dialysis (PD) patients remains unclear. The present study combined clinical data and basic experiments to investigate the impact of baseline PSTR and the underlying molecular mechanisms. A total of 204 incident CAPD patients from four PD centres in Shanghai between 1 January 2014 and 30 September 2020 were grouped based on a peritoneal equilibration test after the first month of dialysi...
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