Internal medicine

Radiology

Blood pressure

Cardiology

Ultrasound

Hemodynamics

Renovascular hypertension

Stenosis

Carotid arteries

Medicine

Objective To dynamically detect the structure and hemodynamic changes of carotid arteries in renovascular hypertensive canine by color ultrasound.Methods The renovascular hypertensive canine model was established by 2 kidney 2 clip (2K2C) method,and the color ultrasound was used to dynamically detect the changes of the inner diameter,intima media thickness (IMT),peak systolic velocity (PSV),resistent index (RI),plaque incidence and Crouse score of carotid arteries in constricted and sham-operated beagles (n=5,respectively).Results The mean Systolic blood pressure (SBP) in constricted beagles was (138.80 ± 9.20) mmHg before operation,and reached a peak value of (171.20 ± 3.56) mmHg three months after operation.Afterward,the SBPs remained stable for up to 1 year,the average SBP was still (168.60 ± 8.88) mmHg,which was significantly higher than the baseline and sham control values (P＜0.01 or P＜0.05,respectively).On the 7th postoperative day,the carotid IMT of constricted and sham-operated beagles were (0.27± 0.03) and (0.26 ± 0.03) mm respectively,and no carotid plaques were detected in 2 groups; twelve months after operation,the IMT in 2 groups IMT incrassated to (0.49 ± 0.01) and (0.38 ± 0.03) mm respectively,and 17 carotid plaques were identified in 5 test beagles,while 4 plaques in 2 of 5 sham animals.The inner diameter,IMT and RI in the postoperative 4th and 12th month were respectively higher than those in the postoperative 7th day within constricted beagles (Pall ＜0.01),but no significant difference was found in the parameters between preoperation and postoperation within sham-operated animals.The IMT in the postoperative 4th and 12th month,and the BI,plaque detection rate and Crouse score in the postoperative 12th month in test beagles were respectively higher than those in sham ones,and there was no significant difference in other parameters between 2 groups.Conclusions The atherosclerotic structure and hemodynamic changes were presented in the carotid arteries of renovascular hypertensive beagles; and the color ultrasound could be used to dynamically identify the occurrence and development of carotid atherrosclerosis.Key words: Renovascular hypertension; Atherosclerosis; Hemodynamic; Ultrasound

Color ultrasound detection on the structure and hemodynamic changes of carotid arteries in renovascular hypertensive canine