Gene

Biology

Virology

Serology

Biochemistry

Botany

Polysaccharide

Immunology

Pneumococcal vaccine

Genetics

Streptococcus pneumoniae

Antibiotics

Bacterial capsule

Microbiology

Capsule

Serotype

Pneumococcal infections

Antibody

Virulence

mBio

The polysaccharide capsule is essential for the pathogenicity of pneumococcus, which is responsible for millions of deaths worldwide each year. Currently available pneumococcal vaccines are designed to elicit antibodies to the capsule polysaccharides of the pneumococcal isolates commonly causing diseases, and the antibodies provide protection only against the pneumococcus expressing the vaccine-targeted capsules. Since pneumococci can produce different capsule polysaccharides and therefore reduce vaccine effectiveness, it is important to track the appearance of novel pneumococcal capsule types and how these new capsules are created. Herein, we describe a new and the 100th pneumococcal capsule type with unique chemical and serological properties. The capsule type was named 10D for its serologic similarity to 10A. Genetic studies provide strong evidence that pneumococcus created 10D capsule polysaccharide by capturing a large genetic fragment from an oral streptococcus. Such interspecies genetic exchanges could greatly increase diversity of pneumococcal capsules and complicate serotype shifts.

A New Pneumococcal Capsule Type, 10D, is the 100th Serotype and Has a Large <i>cps</i> Fragment from an Oral Streptococcus

A New Pneumococcal Capsule Type, 10D, is the 100th Serotype and Has a Large cps Fragment from an Oral Streptococcus