RBR E3 ubiquitin ligases in tumorigenesis
Abstract
RING-in-between-RING (RBR) E3 ligases are one class of E3 ligases that is characterized by the unique RING-HECT hybrid mechanism to function with E2s to transfer ubiquitin to target proteins for degradation. Emerging evidence has demonstrated that RBR E3 ligases play essential roles in neurodegenerative diseases, infection, inflammation and cancer. Accumulated evidence has revealed that RBR E3 ligases exert their biological functions in various...
Paper Details
Title
RBR E3 ubiquitin ligases in tumorigenesis
Published Date
Dec 1, 2020
Journal
Volume
67
Pages
131 - 144
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