MHC-I genotype and tumor mutational burden predict response to immunotherapy

Volume: 12, Issue: 1
Published: May 19, 2020
Abstract
Background Immune checkpoint blockade (ICB) with antibodies inhibiting cytotoxic T lymphocyte-associated protein-4 (CTLA-4) and programmed cell death protein-1 (PD-1) (or its ligand (PD-L1)) can stimulate immune responses against cancer and have revolutionized the treatment of tumors. The influence of host germline genetics and its interaction with tumor neoantigens remains poorly defined. We sought to determine the interaction between tumor...
Paper Details
Title
MHC-I genotype and tumor mutational burden predict response to immunotherapy
Published Date
May 19, 2020
Volume
12
Issue
1
Citation AnalysisPro
  • Scinapse’s Top 10 Citation Journals & Affiliations graph reveals the quality and authenticity of citations received by a paper.
  • Discover whether citations have been inflated due to self-citations, or if citations include institutional bias.