Self-Coiling of Single-Stranded Protofibrils into Rings: A Pathway of Alzheimer’s β-Peptide Amyloidosis on Lipid Membranes

An amyloidosis pathway of Alzheimer's β-peptide Aβ40 on lipid membranes, the self-coiling of single-stranded protofibrils into thermodynamically stable ring structures, is uncovered. Distinct from Aβ amyloid structures reported previously, the coiled rings observed here exhibit a narrow distribution of diameters centered at ∼170 nm and their circumference thicknesses increase as a longer single-stranded protofibril wraps around the ring,...