Abstract 102: Epidermal Nrf2 Orchestrates Tissue Regeneration Through Regulation Of Ccl2

Purpose: Type 2 diabetic (T2D) chronic wounds affect more than 4.5M people in the US and remain the leading cause of non-traumatic amputations. While many signaling pathways are implicated as responders to tissue damage, our work has demonstrated that poor diabetic wound healing is partly due to mismanagement of intracellular oxidative stress that results from dysfunction in the Nrf2/Keap1 signaling pathway. This study focuses on uncovering the...