Original paper
In Vivo Generation of CAR T Cells Selectively in Human CD4+ Lymphocytes
Abstract
T cells modified with CD19-specific chimeric antigen receptors (CARs) result in significant clinical benefit for leukemia patients but constitute a challenge for manufacturing. We have recently demonstrated the in vivo generation of CD19-CAR T cells using the CD8-targeted lentiviral vector (CD8-LV). In this study, we investigated the in vivo generation of CD4+ CAR T cells using CD4-targeted LV (CD4-LV). Administration of CD4-LV into NSG mice...
Paper Details
Title
In Vivo Generation of CAR T Cells Selectively in Human CD4+ Lymphocytes
Published Date
Aug 1, 2020
Journal
Volume
28
Issue
8
Pages
1783 - 1794
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History