Abstract Objective To assess the effects of traditional Chinese medicine (TCM) on the survival of patients with liver cirrhosis (LC) in Southwest China. Design Single-center, ambispective cohort study conducted from 2012 to 2019. Setting Traditional Chinese Medicine Hospital of Dianjiang Chongqing, Southwest China. Main outcome measure The primary outcome was the effect of TCM on the survival of patients with LC, as assessed with survival analysis and Cox regression model. Results Among the 691 patients with LC, 364 (52.68 %) received TCM treatment. The mean (standard deviation) follow-up period was 3.53 (1.62) years for non-TCM users and 4.17 (1.53) years for TCM users (P = 0.184). Multivariate analysis revealed that the use of TCM was associated with a significantly decreased risk of mortality (adjusted hazard ratio [HR] = 0.41, 95 % confidence interval [CI] = 0.30 – 0.54) compared with no TCM use. Similarly, the cumulative mortality rates were significantly lower among TCM users, across various subgroups of LC aetiologies. Among the commonly used TCM prescriptions, Xiao Chaihu Tang (XCHT, adjusted HR = 0.17, 95 % CI = 0.07 – 0.42), Yinchen Wuling San (adjusted HR = 0.31, 95 % CI = 0.14 – 0.66), Biejia Ruan Gan Jian (adjusted HR = 0.31, 95 % CI = 0.13 – 0.75), and Chaihu Shu Gan San (adjusted HR = 0.33, 95 % CI = 0.19 – 0.57) were the most effective in improving survival. Conclusions Our results provide evidence for supporting that adjunctive TCM therapy may potentially improve the survival of patients with liver cirrhosis, and XCHT was the most effective TCM prescription in this study.
#1Maigeng Zhou(CCDC: Chinese Center for Disease Control and Prevention)H-Index: 60
#2Haidong Wang(UW: University of Washington)H-Index: 4
Last. Xiaofeng Liang(CCDC: Chinese Center for Disease Control and Prevention)H-Index: 18
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Summary Background Public health is a priority for the Chinese Government. Evidence-based decision making for health at the province level in China, which is home to a fifth of the global population, is of paramount importance. This analysis uses data from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017 to help inform decision making and monitor progress on health at the province level. Methods We used the methods in GBD 2017 to analyse health patterns in the 34 provin...
Liver fibrosis is characterised by a dense and highly cross-linked extracellular matrix (ECM) which promotes progression of diseases such as hepatocellular carcinoma. The fibrotic microenvironment is characterised by an increased stiffness, with rigidity associated with disease progression. External stiffness is known to promote hepatic stellate cell (HSC) activation through mechanotransduction, leading to increased secretion of ECM components. HSCs are key effector cells which maintain the comp...
Xiaochaihutang (XCHT) is one of classic prescriptions in Treatise on Febrile Diseases in China which was reported to have the effect of anti-hepatic fibrosis in vivo. Activation of hepatic stellate cells (HSCs) is now well established as a central driver of fibrosis in liver injury. Nuclear factor erythroid 2-related factor 2 (Nrf2) is an important element for anti-oxidative damage which is one of the key factors responsible for occurrence. This study was to investigate the effect of XCHT compou...
Background Depression is a common mental disorder. Chai Hu Shu Gan San, a traditional Chinese medicine, is used to treat depression empirically. We present a systematic review and meta-analysis of the therapeutic efficacy and safety of Chai Hu Shu Gan San in treating depression.
Last. Chia-Chou Yeh(TCU: Tzu Chi University)H-Index: 17
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// Tzung-Yi Tsai 1, 2, 3 , Tsung-Hsing Hung 4, 5 , Hanoch Livneh 6 , I-Hsin Lin 7 , Ming-Chi Lu 5, 8 and Chia-Chou Yeh 7, 9 1 Department of Medical Research, Dalin Tzuchi Hospital, The Buddhist Tzuchi Medical Foundation, Chiayi 62247, Taiwan 2 Department of Environmental and Occupational Health, College of Medicine, National Cheng Kung University, Tainan 70428, Taiwan 3 Department of Nursing, Tzu Chi College of Technology, Hualien 97004, Taiwan 4 Division of Gastroenterology, Dalin Tzu Chi Hospi...
Last. Chun-Ping Tang(Guangdong Pharmaceutical University)H-Index: 4
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Objective To investigate the protective effects of Chinese medicine formulation Chaihu Shugan San (柴胡疏肝散, CHSGS) on nonalcoholic fatty liver disease (NAFLD) in rats with insulin resistance (IR) and its molecular mechanisms.
#1Fafeng Cheng(Beijing University of Chinese Medicine)H-Index: 11
#2Chongyang Ma(Beijing University of Chinese Medicine)H-Index: 7
Last. Qingguo Wang(Beijing University of Chinese Medicine)H-Index: 11
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Background Nonalcoholic fatty liver disease (NAFLD) represents one of the most common forms of liver disease worldwide, and it is always regarded as a consequence of a sedentary, food-abundant lifestyle, sitting for an extended time, and a low physical activity level, which often coincide with chronic and long-lasting psychological stress. A Chinese medicine Sinisan (SNS) may be a potential formula for treating this kind of disease.
#2Hanoch Livneh(PSU: Portland State University)H-Index: 38
Last. Chia-Chou Yeh(TCU: Tzu Chi University)H-Index: 17
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Objective Patients with chronic hepatitis B (CHB) are reported to exhibit higher risk of subsequent hepatocellular carcinoma (HCC). However, it remains unclear if Chinese herbal medicine (CHM), an important category of traditional Chinese medicine (TCM), may lower HCC risk in this population. So this study aimed to investigate the effects of CHM on HCC risk among patients with CHB. Methods This cohort study used the Taiwanese National Health Insurance Research Database to identify 21 020 newly d...
#1Yueh Hsiang Liao(PRC: China Medical University (PRC))H-Index: 4
#2Cheng-Chieh Lin(PRC: China Medical University (PRC))H-Index: 62
Last. Tsai-Chung Li(PRC: China Medical University (PRC))H-Index: 53
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Background Traditional Chinese medicine (TCM) is an alternative treatment for cancer with its effect by stimulating host immune response for cytotoxic activity against liver cancer. No studies evaluated TCM treatment on survival of liver cancer patients. Patients and methods This study determined whether the combination of TCM and conventional cancer treatment affects the survival of liver cancer patients. A retrospective cohort study was conducted in 127 237 newly diagnosed liver cancer patient...
Last. Miao Wang(SPU: Shenyang Pharmaceutical University)H-Index: 9
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Hepatic fibrosis (HF) is a typical consequence of various chronic liver diseases, and there is still no ideal drug for its treatment. Yinchen Wuling Powder (YCWLP), a famous traditional Chinese medicine prescription, is effective for the treatment of icteric hepatitis, hepatic fibrosis, non-alcoholic fatty liver disease and other liver diseases in clinical practices, however, the underlying mechanisms of YCWLP on HF is still unclear. In this study, 1H NMR and MS-based metabolomics analysis along...
#1Zhuomao Mo(SYSU: Sun Yat-sen University)H-Index: 4
#2Zhirui Cao(SYSU: Sun Yat-sen University)H-Index: 3
Last. Shijun Zhang(SYSU: Sun Yat-sen University)H-Index: 4
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Aims. Abundant evidences in traditional Chinese medicine (TCM) supported the therapeutic value of herbal medicine Yinchen in hepatocellular carcinoma (HCC), but the underlying mechanism remains to be investigated. Main Methods. The intersection of immune gene set, module genes, HCC-associated genes, and target genes of Yinchen was employed for further analyses. The module genes were identified by weighted gene coexpression network analysis, and the other three gene sets were obtained from public...
Last. Xiaonan Lu(JUTCM: Jiangxi University of Traditional Chinese Medicine)
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Background At present, Liver Cirrhosis (LC) is common in most later liver and gallbladder diseases that its morbidity and mortality seriously affect human health. The limitation and effectiveness of western medicine on LC have become a huge clinical challenge. However, a large number of clinical studies have shown that Yi-guan decoction has become a complementary treatment for LC. Therefore, this systematic review will aim to explore the safety and feasibility of Yi-guan decoction in the treatme...