Original paper
Quantifying genetic effects on disease mediated by assayed gene expression levels
Abstract
Disease variants identified by genome-wide association studies (GWAS) tend to overlap with expression quantitative trait loci (eQTLs), but it remains unclear whether this overlap is driven by gene expression levels ‘mediating’ genetic effects on disease. Here, we introduce a new method, mediated expression score regression (MESC), to estimate disease heritability mediated by the cis genetic component of gene expression levels. We applied MESC to...
Paper Details
Title
Quantifying genetic effects on disease mediated by assayed gene expression levels
Published Date
May 18, 2020
Journal
Volume
52
Issue
6
Pages
626 - 633
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History