Type 2 Diabetes Mellitus

Polyphenol

Type 2 diabetes

Nutritional epidemiology

Proportional hazards model

Endocrinology

Biochemistry

Food science

Environmental health

Quartile

Antioxidant

Internal medicine

Confidence interval

Epidemiology

Hazard ratio

Medicine

Chemistry

Anthropometry

Food group

Diabetes mellitus

Diabetes Metabolic Syndrome and Obesity

The current study aimed to investigate the relationship between daily consumption of total polyphenol and its subclasses and the incidence of diabetes.Eligible adults (n=6,547) were chosen from among participants of the Tehran Lipid and Glucose Study (TLGS) with an average follow-up of 3.0±1.6 years. Dietary intakes were evaluated using a valid and reliable semi-quantitative food frequency questionnaire. Biochemical variables and anthropometrics were evaluated at baseline and follow-up examinations. Multivariate Cox proportional hazard regression models were used to estimate the development of type 2 diabetes mellitus (T2DM) in relation to total intake of polyphenol and its subclasses (flavonoids, phenolic acids, stilbenes, and lignans).This study was conducted on 2,882 men and 3,665 women, aged 41.3±14.6 and 39.0±13.4 years, respectively. The number of participants with the new-onset T2DM was 253. Mean intake of total polyphenol was 346±245 mg/1000 kcal. Risk of type 2 diabetes decreased from quartiles 1 to 4 for total polyphenols (HR: 1.00, 0.37, 0.61, 0.50, Ptrend<0.01), phenolic acids (HR: 1.00, 0.57, 0.49, 0.45, Ptrend<0.01), and lignans (HR: 1.00, 0.67, 0.61, 0.60, Ptrend<0.01), whereas non-significant results were found for flavonoids and stilbenes. This study suggests an inverse association between total intake of polyphenols, phenolic acids, and lignin, and the risk of T2DM.These results emphasize the potential protective role of polyphenol rich food groups (especially fruits and vegetables) in the prevention of T2DM.

&lt;p&gt;The Association of Dietary Polyphenol Intake with the Risk of Type 2 Diabetes: Tehran Lipid and Glucose Study&lt;/p&gt;

&lt;p&gt;The Association of Dietary Polyphenol Intake with the Risk of Type 2 Diabetes: Tehran Lipid and Glucose Study&lt;/p&gt;

<p>The Association of Dietary Polyphenol Intake with the Risk of Type 2 Diabetes: Tehran Lipid and Glucose Study</p>