Abstract 101: Nrf2 Mediates Angiogenic Function Of Endothelial Cells Through Regulation Of Cxcr4/sdf-1 Axis

Purpose: Diabetes mellitus is the leading cause of non-healing wounds, with chronic wounds costing the US healthcare system up to 31.7 billion dollars annually. Diabetes negatively affects the soft tissue healing via dysregulations of redox homeostasis and angiogenesis. We have previously shown that inadequate signaling of Nrf2, a master transcriptional regulator of antioxidant response signaling, contributes to the oxidative stress underlying...