Nuclear chemistry

Catalysis

Linguistics

Engineering

Philosophy

Oxide

Photocurrent

Photoelectrochemistry

Electrochemistry

Metallurgy

Materials science

Chromatography

Zero (linguistics)

Tin oxide

Biochemistry

Chemical engineering

Food science

Anatase

Physical chemistry

Titanium dioxide

Rutile

Nanotechnology

Organic chemistry

Chemistry

Electrode

Ascorbic acid

Photocatalysis

Detection limit

Optoelectronics

Journal of Solid State Electrochemistry

A novel label-free photoelectrochemical immunosensor was developed for the determination of prostate-specific antigen (PSA) based on fluorine-doped tin oxide (FTO) electrode modified with anatase and rutile titanium dioxide nanoparticles (TiO2(a-r)) as a platform for the electrodeposition of bismuth sulfide (Bi2S3). The photoelectrochemical response of the TiO2(a-r) platform sensitized with Bi2S3 for the ascorbic acid donor molecule (AA) was about 34-fold higher than that observed in the absence of Bi2S3. The Bi2S3/TiO2(a-r)/FTO platform was modified with PSA antibodies to produce the anti-PSA/Bi2S3/TiO2(a-r)/FTO immunosensor, which was incubated in solutions of PSA antigen to inhibit the photocurrent of the immunosensor for AA. The photocurrent of the anti-PSA/Bi2S3/TiO2(a-r)/FTO immunosensor presented a linear relationship with the logarithm of the PSA concentration ranging from 1 pg mL−1 to 100 ng mL−1 with good sensitivity and a limit of detection of 0.870 pg mL−1. The sensor was successfully employed for the determination of PSA in artificial blood plasma samples, with recoveries between 94.6 and 98.6%.

Highly sensitive photoelectrochemical immunosensor based on anatase/rutile TiO2 and Bi2S3 for the zero-biased detection of PSA