Physiological Stratification of Patients With Angina Due to Coronary Microvascular Dysfunction

Coronary microvascular dysfunction (CMD) is defined by diminished flow reserve. Functional and structural CMD endotypes have recently been described, with normal and elevated minimal microvascular resistance, respectively. This study determined the mechanism of altered resting and maximal flow in CMD endotypes. A total of 86 patients with angina but no obstructive coronary disease underwent coronary pressure and flow measurement during rest,...