Original paper
Systemic short chain fatty acids limit antitumor effect of CTLA-4 blockade in hosts with cancer
Abstract
Gut microbiota composition influences the clinical benefit of immune checkpoints in patients with advanced cancer but mechanisms underlying this relationship remain unclear. Molecular mechanism whereby gut microbiota influences immune responses is mainly assigned to gut microbial metabolites. Short-chain fatty acids (SCFA) are produced in large amounts in the colon through bacterial fermentation of dietary fiber. We evaluate in mice and in...
Paper Details
Title
Systemic short chain fatty acids limit antitumor effect of CTLA-4 blockade in hosts with cancer
Published Date
May 1, 2020
Journal
Volume
11
Issue
1
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Notes
History