Review paper

Validation of serum neurofilaments as prognostic and potential pharmacodynamic biomarkers for ALS

Volume: 95, Issue: 1
Published: Jul 7, 2020
Abstract
To identify preferred neurofilament assays and clinically validate serum neurofilament light (NfL) and phosphorylated neurofilament heavy (pNfH) as prognostic and potential pharmacodynamic biomarkers relevant to amyotrophic lateral sclerosis (ALS) therapy development.In this prospective, multicenter, longitudinal observational study of patients with ALS (n = 229), primary lateral sclerosis (n = 20), and progressive muscular atrophy (n = 11),...
Paper Details
Title
Validation of serum neurofilaments as prognostic and potential pharmacodynamic biomarkers for ALS
Published Date
Jul 7, 2020
Journal
Volume
95
Issue
1
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